The Pathophysiology Of Celiac Disease - 2023 Words

Celiac disease is a T-cell-mediated, autoimmune, genetic illness that targets the small intestine in which the absorption of nutrients, particularly fats, is impaired. The disease has been described as â€Å"a permanent intolerance to ingested gluten that damages the small intestine, characteristically inducing crypt hyperplasia and villous atrophy, and typically resolves with removal of gluten from the diet.† (AJN 34). Celiac disease appears to be more prevalent in women than in men. Genetic and immune factors are known to play a role in its development. People that have a family member with celiac disease and people that have autoimmune disorders are at higher risk to develop celiac disease. This paper outlines the pathophysiology of celiac disease, discusses signs and symptoms, the four disease types, describes testing, treatment, addresses the differences between gluten-free diet and a diet containing gluten, the use of dietary supplements, and vitamin D status. Most absorption of nutrients occurs in the small intestine. The mucosa of the small intestine is arranged in microscopic folds, which in turn contain even smaller finger-like projections called villi. The cells of the villi are covered with microscopic hairs, microvilli, projecting from the cell membrane. The folds, villi, and microvilli of the intestinal mucosa provide a huge surface area for nutrient absorption. Cells of the intestines are specialized to absorb different nutrients. Readily digested nutrients areShow MoreRelatedThe Pathophysiology Of Celiac Disease1743 Words   |  7 PagesThe Pathophysiology of Celiac Disease Celiac disease (CD) is an autoimmune disorder involving both innate and adaptive immune responses that occurs among genetically-predisposed subjects who are exposed to gluten-containing foods (Green et al. 2015). People of all ages, genders, and races can develop CD (Fasano and Catassi 2012). 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